1) FOUL TROUBLE

-It's not secret that the Big East is a physical league, and the referees of that league allow that kind of play.  But when it comes to the NCAA Tournament, the refs might not allow that kind of play.  And frnakly, Peyton Siva and Russ Smith want to put their hands all over you, and play as physical as possible.  If those guys get 2 first half fouls each, who becomes the consistent scorer for the Cards?

2) CHANE AND WAYNE

-These two were supposed to be a dynamic duo for the Cards.  They might still be the most talented players on the roster.  But both of them lack a consistency you likely need from key players in the tournament.  UofL has been lucky that usually one guy or the other plays well.  But what if both are off in the Sweet 16 or Elite 8?  It could be lights out for UL.

3) PITINO LATE GAME COACHING

-Rick Pitino is a Hall of Famer.  He can truly do it all....except it seems diagram a late-game play.  Look at Notre Dame.  Had 5 chances to win that game and never drew up a play that seemed to have anything besides 1-on-1 play.  Or maybe Russ Smith just hijacked the endings.  Either way, Pitino has a history of failures to draw up a good play late in games, even at Kentucky.  Last year, he really didn't need it until the Elite 8, and it worked out.  But history with Pitino shows it might not always be that way.

4) REGION OF DEATH

-Missouri was a Top 10 team in the preseason.  Saint Louis is one of the hottest teams in the country.  Michigan State has more postseason success than any team in the last 10 years.  And Duke is Duke.  The gauntlet of potential games is rough.  Even this good of a UL team can struggle with that slate of games.  Not to mention any Final Four is gonna be a challenge.  Point being: it's hard to win 6 straight games.

5) PRESSURE

-When you are the #1 overall seed, the pressure is amped up times 10.  Kentucky was more of the exception to the rule last season.  Number 1 overall seeds rarely win the tournament.  Think Louisville 2009.  Think Kansas 2010.  Think Ohio State 2011.  None of those teams even made the Final Four.  And now you are going to ask these guys to win 6 in a row.  UL had no pressure last season on their run to the Final Four.  This year will be something they will have never experienced.